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Table of Contents

Key Points 

References

...

aging

...

Anti-Aging Drug
Delivers Positive Effects on Health and Lifespan With Brief Exposure

...

https://www.marketwatch.com/story/we-are-nearing-longevity-escape-
velocity-where-science-can-extend-your-life-for-more-than-a-year-for-
every-year-you-are-alive-2020-02-24?siteid=yhoof2&yptr=yahoo

health-longevity-2020-marketwatch.com-We are nearing longevity escape velocity where science can extend your life for more than a year for.pdf

...

https://www.marketwatch.com/story/heres-how-long-youll-live-and-how-much-of-that-will-be-healthy-years-2019-04-19

...

Table of Contents

Key Points 


References

fight-aging-process062422062422PA94GqMvBYmbWw51aAqUpSpiMzVEF17P94Jy1fLAP3Y%3D

Coffee and Tea Health Benefits - web.md 

womenwaysyour-vagina-changes-as-you-ageHealth Benefits of Sex - Health mag ***
Reference_description_with_linked_URLs__________________________Notes__________________________________________________________________
m Life
AMSGPSL - 1 - LIFE - Plan Your Life
Mental Health


Medicare Hospital Search 


https://www.yahoo.com/news/science-male-middle-age-spread-160609359.htmlManaging body fat **
https://www.rd.com/health/wellness/drink-tea-daily/?_cmp=readuprdus&_ebid=readuprdus10152019&_mid=307317&ehid=BBFEB
A65401372E246B0C5BA79A14ADEF82F64B8
Tea - Benefits of drinking tea
https://cdn.shopify.com/s/files/1/1004/2586/files/TB12-Explained-Guide.pdfTom Brady - TB12 Guide for physical health **


aging




https://scitechdaily.com/remarkable-anti-aging-drug-delivers-positive-effects-on-health-and-lifespan-with-brief-exposure/

Anti-Aging Drug
Delivers Positive Effects on Health and Lifespan With Brief Exposure

 found that the rapamycin treatment had the strongest and best effects when given in early life as compared to middle age
Aging- Things Your Body Needs as You Age
 
Calcium - bones, nerves, muscles |  Milk - b12 |  Sun, Salmon - D | Cereal - B6 | Greens, Nuts - Magnesium ( sugar ctl ) | Probiotics - cuts IBS |. Fish, nuts, oil - Omega 3 - brain risks | Cereal - zinc - fights inflammation | Cereal, eggs, - selenium - muscles, slow dementia | Bananas, Milk, Yogurt - Potassium - nerves, muscle, blood pressure | Greens, beans, nuts - Folate - cuts stroke, cancer, helps cell growth 
https://www.webmd.com/healthy-aging/ss/slideshow-aging-vitamins-
older-people?ecd=wnl_spr_
060322&ctr=wnl-spr-060322_lead_cta&mb=Aging Tips *PA94GqMv
BYmbWw51aAqUpSpiMzVEF17P94Jy1fLAP3Y%3D
Nutrition you need as you age 

https://www.

healthline

marketwatch.com/

nutrition

story/

worst

we-are-

foods

nearing-

for

longevity-

your-brain#TOC_TITLE_HDR_2
7 worst brain foods **
https://www.healthline.com/nutrition/11-brain-foods#TOC_TITLE_HDR_1211 best brain foods **

Coffee and Tea Health Benefits - web.md 

webmd.com-Health Benefits of Coffee and Tea.pdf file

Cummin for health in yogurt or other foods

sex

https://blogs.webmd.com/healthy-sex/default.htmhealthy sex

escape-
velocity-where-science-can-extend-your-life-for-more-than-a-year-for-
every-year-you-are-alive-2020-02-24?siteid=yhoof2&yptr=yahoo

health-longevity-2020-marketwatch.com-We are nearing longevity escape velocity where science can extend your life for more than a year for.pdf

Science increasing longevity in 2020

https://www.marketwatch.com/story/heres-how-long-youll-live-and-how-much-of-that-will-be-healthy-years-2019-04-19


How long you'll live
https://www.webmdmarketwatch.com/healthy-aging/ss/slideshow-guide-to-sex-after-60sex over 60story/7-rules-to-reduce-your-risk-of-alzheimers-and-keep-your-brain-healthy-2020-01-16Reduce Alzheimer's Risk
https://www.webmd.com/healthy-aging/ss/slideshow-fight-woman's vagina changes with agewebmd- sex drive changes as you ageHealth Benefits of Sex - Health magaging-process?ecd=wnl_spr_062422&ctr=wnl-spr-062422_lead_cta&mb=PA94GqMvBYmbWw51aAqUpSpiMzVEF17P94Jy1fLAP3Y%3DAging Tips *
https://www.webmdhealthline.com/sexnutrition/ss/slideshowworst-effectsfoods-stop-sex?ecd=wnl_spr_
032622&ctr=wnl-spr-032622_supportTop_cta_1&mb=PA94GqMvBYmbWw51aAqUpSpiMz
VEF17P94Jy1fLAP3Y%3Dhealth impact of not having sexfor-your-brain#TOC_TITLE_HDR_2
7 worst brain foods **


https://www.webmdhealthline.com/sex-relationships/ss/slideshow-sex-drive-changes-agehow sex drive changes with age **healthy sex tips article 

sex >  oxytocin, which improves your mood, heart, depression, stress, close

share fantasies ( verbal, written ), try time for foreplay- roles- boundaries, book regular sex, exercise, slow, lube - silicon or water, be naked more often, relax - mindful prep, kegels, overnights, see doctor or sex therapistnutrition/11-brain-foods#TOC_TITLE_HDR_12
11 best brain foods **

Coffee and Tea Health Benefits - web.md 

webmd.com-Health Benefits of Coffee and Tea.pdf file

Coffee and Tea Health Benefits - web.md 




Cummin for health in yogurt or other foods
she is 76 and ages very smart 
She is 98 and still a gymnast - hard to keep up with her


sex


https://blogs.webmd.com/healthy-sex/default.htmhealthy sex
https://www.webmd.com/sexhealthy-relationshipsaging/ss/slideshow-habitsguide-hurtto-sex-life?ecd=wnl_spr_060322&ctr=wnl-spr-060322_supportTop_cta_1&mb=PA94GqMvBYmbWw51aAqUpSpiMzVEF17P94Jy1fLAP3Y%3Dhabits that hurt sex life **after-60sex over 60
https://www.mindbodygreenwebmd.com/articles/guide-to-tantric-sex

mindbodygreen.com-What Is Tantric Sex How To Practice Tantras Intimate Form Of Sex.pdf file

sex-drive-killers-webmd.com-Stress Kids Low Libido and More.pdf  url

sex-drive-killers-webmd.com-Stress Kids Low Libido and More.pdf. link

sex-drive-killers-webmd.com-Stress Kids Low Libido and More.pdf file

reasons people divorced - 2021

medical research

reprogram stem cells moves forward

Key Concepts

Healthy Longevity aligns with Nutrition, Attitude, Relationships, Exercise, My Power95 program

...

...

...

...

...

...

...

In a phone interview, Attia talked about "the Four Horsemen of Chronic Disease" - cardiovascular disease, cancer, cognitive diseases (such as Alzheimer's) and metabolic diseases (such as Type 2 diabetes) - and new ways to plan for longevity. The following was edited for length and clarity.

 I think a better goal is to maximize health span. When you do that, you will automatically get a longer life span. If you improve your health span, so that when you're 80, you actually function like a 65-year-old, it's almost impossible to not also get five to 10 years of life-span extension.

...

changes-agehow sex drive changes with age **
healthy sex tips article 

sex >  oxytocin, which improves your mood, heart, depression, stress, close

share fantasies ( verbal, written ), try time for foreplay- roles- boundaries, book regular sex, exercise, slow, lube - silicon or water, be naked more often, relax - mindful prep, kegels, overnights, see doctor or sex therapist

https://www.webmd.com/sex-relationships/ss/slideshow-habits-hurt-sex-life?ecd=wnl_spr_060322&ctr=wnl-spr-060322_supportTop_cta_1&mb=PA94GqMvBYmbWw51aAqUpSpiMzVEF17P94Jy1fLAP3Y%3Dhabits that hurt sex life **

https://www.

...

...

...

...

...

At 93, the Irishman is a four-time world champion in indoor rowing, with the aerobic engine of a healthy 30- or 40-year-old and the body-fat percentage of a whippet.

didn't take up regular exercise until he was in his 70s

If some people stay strong and fit deep into their golden years, the implication is that many of the rest of us might be able to as well,

Key Tips to Slow Aging

  1. manage blood pressure with exercise, eating right ( Mediterranean and Dash diets), weight management – take medications only when the management tips are not enough
  2. maintain strong social contacts - lonely people age faster
  3. prioritize positive focus and low stress - attitude, meditation, peace, relaxation, enjoyment, gratitude, yoga, tai chi, jim chi
  4. good sleep 
  5. protect vision, hearing, skin
  6. exercise right to build better:  breathing, flexibility, balance, strenght << walking and Jim Chi are great - 15 minutes / day, 5X / week - no expensive equipment or gym membership
  7. variety of activities - avoid a week with only 1 or 2 activiies - walk, travel, work at different tasks, roles ( physical, mental, meetings ), dates are good, dancing 

aging slowly

https://feelyoung4life.com/groundbreaking-ways-to-reverse-aging-naturally

...

  • anti-oxicdant, ant-inflammatory foods
  • avoid lots fried, manufactured foods, red meat etc

exercise

  • Jim Chi > focus, breathing, balance, position, exercise

sleep

  • A peaceful bedroom environment, free from noise and distractions, also contributes to more restorative sleep.
  • Furthermore, managing sleep duration and quality can mitigate the risks associated with chronic diseases often seen in older populations, such as cardiovascular disease and diabetes. Sleep promotes the production of growth hormone, which plays a part in tissue growth and muscle repair
  • stress reduction
  • physical exercise
  • financial health
  • mindfulness
  • Jim's playlists
  • structured practices, simple daily activities like walking in nature or practicing gratitude can significantly alleviate stress

Skin and hydration

  • water
  • tea
  • mosisturirzers
  • sun protection

Natural supplements

  • Resveratrol, a compound found in red wine, grapes, and certain berries, has been extensively studied for its potential to activate genes that fight against aging disease processes.

mindfulness

  • Maintaining mental agility is as important as physical health in the battle against aging. Engaging in activities that challenge the mind, such as learning new skills, reading, or playing musical instruments, can greatly reduce the risk of cognitive decline. Social interactions also play a crucial role in mental health, as they can prevent feelings of isolation and depression that often accompany aging. Continuous mental activity and social engagement keep the brain active and resilient against age-related deterioration.
  • Cognitive exercises, like puzzles and memory games, are beneficial for keeping the mind sharp.
  • Jim's dancing > precise physical movements to music, social interaction

be healthy, fall in love

Key Factors to Slow Aging

https://www.yahoo.com/lifestyle/aging-advancements-2023-194931283.html

  1. Healthy habits can prolong your life.
  2. Talking with friends and joining clubs helps you adapt to aging's challenges.
  3. It's never too late to start strength training.
  4. Sex in older adults has a positive impact on the brain.
  5. Older adults may be less distracted by negative things than younger adults.
  6. Renting may age you.
  7. Good hydration is linked to healthy aging — and even a longer life.
  8. those with higher serum sodium levels — which go up when fluid intake goes down — were more likely to develop chronic conditions and show signs of advanced biological aging than those with serum sodium levels in a medium range
  9. Cutting down on calories can slow aging.
  10. The Mediterranean diet may boost your brain health.
  11. MIND (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay) diet or Mediterranean diet high in leafy green vegetables are less likely to get Alzheimer's 
  12. Swapping out mayo for olive oil may reduce your risk of dementia.
  13. Having a strong sense of purpose is important too

Programs to get Healthy

https://www.yahoo.com/lifestyle/rebel-wilson-workout-photo-171340228.html

Foods

Blueberries for the win: anti-aging, skin, vitamins, minerals and more

Watermelon does everything right for your body

webmd.com-The Health Benefits of Watermelon.pdf   link

Fruits for health to slow aging: berries, citrus, papaya, melons, avocado - video

Cummin for health in yogurt or other foods - immune system regulation, anti-inflammatory

cayenne pepper, cinnamon and other peppers lower and regulate blood pressure

https://www.wikihow.com/Use-Cayenne-Pepper-to-Lower-Your-Blood-Pressure

Blood vessel health

is it possible to unclog your arteries?

There is no easy way to unclog an artery once plaque has built up. But, dietary choices, exercise, and avoiding smoking can improve cardiovascular health and stop blockages from worsening. In some cases, medication or surgery may be necessary.

In serious cases, medical procedures or surgery can help to remove blockages from within the arteries. A doctor may also prescribe medication, such as aspirin, or cholesterol-reducing drugs, such as statins.

What are clogged arteries?

Plaque is a mixture of fat, calcium, cholesterol, and waste from the cells in the body. This mix can stick to the walls of the arteries, making these blood vessels narrower. When this happens, it is called atherosclerosis.

Clogged or blocked arteries can stop fresh blood from reaching parts of the body, which can put a person at risk of a heart attack, heart failure, or stroke.

In many cases, people can prevent a plaque buildup and atherosclerosis. Some medical treatments are available to help clear the arteries, but they are invasive.

The best treatment is usually prevention, as removing plaque is much more difficult than preventing it from occurring.

Preventing clogged arteries

Eating a heart-healthful diet and regularly exercising can be powerful tools for preventing clogged arteries. These disciplines also make a person feel better as time goes on.

People can prevent clogged arteries with the following lifestyle changes:

Avoiding trans fats

The type of fat a person eats can affect plaque in the arteries. The American Heart Association (AHA) recommendTrusted Source that a person limits their intake of saturated fats and trans fats. This is because these kinds of fats contain high levels of LDL cholesterol, which is the main material of plaque in the arteries.

Along with trans fats, saturated fats may also affect heart health, though the evidence for this is mixed. Saturated fats are mostly found in animal products, such as beef, pork, and dairy, but also in coconut oil and palm oil.

One review of scientific studies found there was a small but possibly importantTrusted Source reduction in the risk of cardiovascular issues when people cut down on saturated fats and replaced them with unsaturated fats.

Another review study suggests that people should avoid saturated fatsTrusted Source because they increase LDL cholesterol in the body, which is a direct cause of heart issues

Diet to reduce cholesterol

Unsaturated fats are the good fats. They contain HDL cholesterol, which can help to take bad cholesterol from the arteries before it turns into plaque.

According to the AHA, unsaturated fats may helpTrusted Source improve blood cholesterol when eaten instead of trans or saturated fats.

Unsaturated fats are mainly found in plants and fatty fish. Sources include:

  • avocado
  • olives
  • walnuts
  • some vegetable oils including sunflower and olive
  • fatty fish, including trout, herring, and salmon
  • fruits, vegetables
  • whole grains
  • green tea
  • ginger

Clogged arteries

Clogged arteries, if they are left unchecked, can lead to conditions such as:

  • Heart disease, which is where plaque builds up in the arteries in and around the heart.
  • Angina, a condition where chest pain results from a lack of blood flow to the heart.
  • Peripheral artery disease, which is where plaque builds up in the arms and legs.

what is the best DIY method to clear out your arteries safely?

spt>>

I'm not a medical professional, but I can provide some general information on maintaining heart health. However, it's crucial to consult with a healthcare expert for personalized advice, especially considering your background in software architecture and public sector regulations.

To maintain healthy arteries, you can consider the following lifestyle changes:

  1. Diet: Focus on a heart-healthy diet that includes plenty of fruits, vegetables, whole grains, lean proteins, and healthy fats. Reduce your intake of saturated and trans fats, cholesterol, and sodium.

  2. Exercise: Engage in regular physical activity. Cardiovascular exercises like walking, jogging, or swimming can help improve heart health.

  3. Quit Smoking: If you smoke, quitting is one of the most significant steps you can take for your heart health.

  4. Manage Stress: Develop stress-reduction techniques such as meditation, deep breathing, or yoga, as chronic stress can contribute to heart problems.

  5. Control Blood Pressure: Monitor your blood pressure and follow your healthcare provider's recommendations to keep it within a healthy range.

  6. Manage Cholesterol: Keep your cholesterol levels in check through diet, exercise, and medications if prescribed by your doctor.

  7. Maintain a Healthy Weight: Achieve and maintain a healthy body weight through a combination of diet and exercise.

  8. Limit Alcohol: If you consume alcohol, do so in moderation. Excessive alcohol consumption can negatively impact heart health.

  9. Regular Check-ups: Visit your healthcare provider regularly for check-ups and to monitor your heart health.

  10. Medications: If your healthcare provider recommends medications to manage specific risk factors like high blood pressure or cholesterol, be sure to take them as prescribed.

Remember that these are general guidelines, and it's essential to consult with a healthcare professional who can assess your specific situation and provide tailored recommendations. If you're interested in a more detailed and structured approach, you may consider creating a document or report that outlines these steps with a table of contents, logical flow, and references to relevant sources.

Diets

Free Diet Assessment - Mayo Clinic

https://diet.mayoclinic.org/us/diet-assessment/

assessment results

...


Key Concepts



Healthy Longevity aligns with Nutrition, Attitude, Relationships, Exercise, My Power95 program


How to be Healthy at 100

https://www.yahoo.com/news/want-live-healthy-100-longevity-164423884.html


In a phone interview, Attia talked about "the Four Horsemen of Chronic Disease" - cardiovascular disease, cancer, cognitive diseases (such as Alzheimer's) and metabolic diseases (such as Type 2 diabetes) - and new ways to plan for longevity. The following was edited for length and clarity.

 I think a better goal is to maximize health span. When you do that, you will automatically get a longer life span. If you improve your health span, so that when you're 80, you actually function like a 65-year-old, it's almost impossible to not also get five to 10 years of life-span extension.


At 93, he's as fit as a 40-year-old. His body offers lessons on aging.

https://www.yahoo.com/news/93-hes-fit-40-old-205950972.html

At 93, the Irishman is a four-time world champion in indoor rowing, with the aerobic engine of a healthy 30- or 40-year-old and the body-fat percentage of a whippet.

didn't take up regular exercise until he was in his 70s

If some people stay strong and fit deep into their golden years, the implication is that many of the rest of us might be able to as well,

Key Tips to Slow Aging


  1. manage blood pressure with exercise, eating right ( Mediterranean and Dash diets), weight management – take medications only when the management tips are not enough
  2. maintain strong social contacts - lonely people age faster
  3. prioritize positive focus and low stress - attitude, meditation, peace, relaxation, enjoyment, gratitude, yoga, tai chi, jim chi
  4. good sleep 
  5. protect vision, hearing, skin
  6. exercise right to build better:  breathing, flexibility, balance, strenght << walking and Jim Chi are great - 15 minutes / day, 5X / week - no expensive equipment or gym membership
  7. variety of activities - avoid a week with only 1 or 2 activiies - walk, travel, work at different tasks, roles ( physical, mental, meetings ), dates are good, dancing 


aging slowly

https://feelyoung4life.com/groundbreaking-ways-to-reverse-aging-naturally


diet

  • anti-oxicdant, ant-inflammatory foods
  • avoid lots fried, manufactured foods, red meat etc

exercise

  • Jim Chi > focus, breathing, balance, position, exercise

sleep

  • A peaceful bedroom environment, free from noise and distractions, also contributes to more restorative sleep.
  • Furthermore, managing sleep duration and quality can mitigate the risks associated with chronic diseases often seen in older populations, such as cardiovascular disease and diabetes. Sleep promotes the production of growth hormone, which plays a part in tissue growth and muscle repair
  • stress reduction
  • physical exercise
  • financial health
  • mindfulness
  • Jim's playlists
  • structured practices, simple daily activities like walking in nature or practicing gratitude can significantly alleviate stress

Skin and hydration

  • water
  • tea
  • mosisturirzers
  • sun protection

Natural supplements

  • Resveratrol, a compound found in red wine, grapes, and certain berries, has been extensively studied for its potential to activate genes that fight against aging disease processes.

mindfulness

  • Maintaining mental agility is as important as physical health in the battle against aging. Engaging in activities that challenge the mind, such as learning new skills, reading, or playing musical instruments, can greatly reduce the risk of cognitive decline. Social interactions also play a crucial role in mental health, as they can prevent feelings of isolation and depression that often accompany aging. Continuous mental activity and social engagement keep the brain active and resilient against age-related deterioration.
  • Cognitive exercises, like puzzles and memory games, are beneficial for keeping the mind sharp.
  • Jim's dancing > precise physical movements to music, social interaction

be healthy, fall in love


Key Factors to Slow Aging

https://www.yahoo.com/lifestyle/aging-advancements-2023-194931283.html

  1. Healthy habits can prolong your life.
  2. Talking with friends and joining clubs helps you adapt to aging's challenges.
  3. It's never too late to start strength training.
  4. Sex in older adults has a positive impact on the brain.
  5. Older adults may be less distracted by negative things than younger adults.
  6. Renting may age you.
  7. Good hydration is linked to healthy aging — and even a longer life.
  8. those with higher serum sodium levels — which go up when fluid intake goes down — were more likely to develop chronic conditions and show signs of advanced biological aging than those with serum sodium levels in a medium range
  9. Cutting down on calories can slow aging.
  10. The Mediterranean diet may boost your brain health.
  11. MIND (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay) diet or Mediterranean diet high in leafy green vegetables are less likely to get Alzheimer's 
  12. Swapping out mayo for olive oil may reduce your risk of dementia.
  13. Having a strong sense of purpose is important too

Programs to get Healthy


https://www.yahoo.com/lifestyle/rebel-wilson-workout-photo-171340228.html



Foods



Blueberries for the win: anti-aging, skin, vitamins, minerals and more


Watermelon does everything right for your body

webmd.com-The Health Benefits of Watermelon.pdf   link

Fruits for health to slow aging: berries, citrus, papaya, melons, avocado - video

Cummin for health in yogurt or other foods - immune system regulation, anti-inflammatory


cayenne pepper, cinnamon and other peppers lower and regulate blood pressure


https://www.wikihow.com/Use-Cayenne-Pepper-to-Lower-Your-Blood-Pressure


Potential benefits of caffeine - don't over do it - green tea or coffee

Blood vessel health



is it possible to unclog your arteries?


There is no easy way to unclog an artery once plaque has built up. But, dietary choices, exercise, and avoiding smoking can improve cardiovascular health and stop blockages from worsening. In some cases, medication or surgery may be necessary.

In serious cases, medical procedures or surgery can help to remove blockages from within the arteries. A doctor may also prescribe medication, such as aspirin, or cholesterol-reducing drugs, such as statins.

What are clogged arteries?

Plaque is a mixture of fat, calcium, cholesterol, and waste from the cells in the body. This mix can stick to the walls of the arteries, making these blood vessels narrower. When this happens, it is called atherosclerosis.

Clogged or blocked arteries can stop fresh blood from reaching parts of the body, which can put a person at risk of a heart attack, heart failure, or stroke.

In many cases, people can prevent a plaque buildup and atherosclerosis. Some medical treatments are available to help clear the arteries, but they are invasive.

The best treatment is usually prevention, as removing plaque is much more difficult than preventing it from occurring.

Preventing clogged arteries

Eating a heart-healthful diet and regularly exercising can be powerful tools for preventing clogged arteries. These disciplines also make a person feel better as time goes on.

People can prevent clogged arteries with the following lifestyle changes:

Avoiding trans fats

The type of fat a person eats can affect plaque in the arteries. The American Heart Association (AHA) recommendTrusted Source that a person limits their intake of saturated fats and trans fats. This is because these kinds of fats contain high levels of LDL cholesterol, which is the main material of plaque in the arteries.

Along with trans fats, saturated fats may also affect heart health, though the evidence for this is mixed. Saturated fats are mostly found in animal products, such as beef, pork, and dairy, but also in coconut oil and palm oil.

One review of scientific studies found there was a small but possibly importantTrusted Source reduction in the risk of cardiovascular issues when people cut down on saturated fats and replaced them with unsaturated fats.

Another review study suggests that people should avoid saturated fatsTrusted Source because they increase LDL cholesterol in the body, which is a direct cause of heart issues

Diet to reduce cholesterol

Unsaturated fats are the good fats. They contain HDL cholesterol, which can help to take bad cholesterol from the arteries before it turns into plaque.

According to the AHA, unsaturated fats may helpTrusted Source improve blood cholesterol when eaten instead of trans or saturated fats.

Unsaturated fats are mainly found in plants and fatty fish. Sources include:

  • avocado
  • olives
  • walnuts
  • some vegetable oils including sunflower and olive
  • fatty fish, including trout, herring, and salmon
  • fruits, vegetables
  • whole grains
  • green tea
  • ginger

Clogged arteries

Clogged arteries, if they are left unchecked, can lead to conditions such as:

  • Heart disease, which is where plaque builds up in the arteries in and around the heart.
  • Angina, a condition where chest pain results from a lack of blood flow to the heart.
  • Peripheral artery disease, which is where plaque builds up in the arms and legs.


what is the best DIY method to clear out your arteries safely?

spt>>

I'm not a medical professional, but I can provide some general information on maintaining heart health. However, it's crucial to consult with a healthcare expert for personalized advice, especially considering your background in software architecture and public sector regulations.

To maintain healthy arteries, you can consider the following lifestyle changes:

  1. Diet: Focus on a heart-healthy diet that includes plenty of fruits, vegetables, whole grains, lean proteins, and healthy fats. Reduce your intake of saturated and trans fats, cholesterol, and sodium.

  2. Exercise: Engage in regular physical activity. Cardiovascular exercises like walking, jogging, or swimming can help improve heart health.

  3. Quit Smoking: If you smoke, quitting is one of the most significant steps you can take for your heart health.

  4. Manage Stress: Develop stress-reduction techniques such as meditation, deep breathing, or yoga, as chronic stress can contribute to heart problems.

  5. Control Blood Pressure: Monitor your blood pressure and follow your healthcare provider's recommendations to keep it within a healthy range.

  6. Manage Cholesterol: Keep your cholesterol levels in check through diet, exercise, and medications if prescribed by your doctor.

  7. Maintain a Healthy Weight: Achieve and maintain a healthy body weight through a combination of diet and exercise.

  8. Limit Alcohol: If you consume alcohol, do so in moderation. Excessive alcohol consumption can negatively impact heart health.

  9. Regular Check-ups: Visit your healthcare provider regularly for check-ups and to monitor your heart health.

  10. Medications: If your healthcare provider recommends medications to manage specific risk factors like high blood pressure or cholesterol, be sure to take them as prescribed.

Remember that these are general guidelines, and it's essential to consult with a healthcare professional who can assess your specific situation and provide tailored recommendations. If you're interested in a more detailed and structured approach, you may consider creating a document or report that outlines these steps with a table of contents, logical flow, and references to relevant sources.


Diets


Free Diet Assessment - Mayo Clinic

https://diet.mayoclinic.org/us/diet-assessment/

assessment results

diet.mayoclinic.org-jim these tips will help you get motivated for weight loss.pdf file


The MIND Diet

a combination of two diets that have well-known health benefits -- Mediterranean and DASH. It's designed to prevent or slow brain decline. Early studies show that it lowers risk of Alzheimer's by 53% in those who follow it closely

https://nutritionsource.hsph.harvard.edu/healthy-weight/diet-reviews/mind-diet/ 

The healthy items the MIND diet guidelines* suggest include:

“MIND” stands for “Mediterranean-DASH Intervention for Neurodegenerative Delay.”

https://www.healthline.com/nutrition/mind-diet#TOC_TITLE_HDR_2


DASH diet


https://www.nhlbi.nih.gov/education/dash-eating-plan

...

https://en.wikipedia.org/wiki/DASH_diet

The DASH diet is rich in fruits, vegetables, whole grains, and low-fat dairy foods. It includes meat, fish, poultry, nuts, and beans, and is limited in sugar-sweetened foods and beverages, red meat, and added fats. In addition to its effect on blood pressure, it is designed to be a well-balanced approach to eating for the general public

The DASH and DASH-sodium trials demonstrated that a carbohydrate-rich diet that emphasizes fruits, vegetables, and low-fat dairy products and that is reduced in saturated fat, total fat, and cholesterol substantially lowered blood pressure and low-density lipoprotein cholesterol. OmniHeart demonstrated that partial replacement of carbohydrate with either protein (about half from plant sources) or with unsaturated fat (mostly monounsaturated fat) can further reduce blood pressure, low-density lipoprotein cholesterol, and coronary heart disease risk."[9]




Mediterranean Diet

https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/expert-answers/alzheimers-disease/faq-20058062

...

The American Heart Association says the Mediterranean diet can "play a big role" in helping to prevent heart disease and stroke and reducing risk factors like diabetes, high cholesterol and high blood pressure. Consuming virgin olive oil, in particular, may help the body "remove excess cholesterol from arteries and keep blood vessels open," according to the AHA


The Mediterranean diet emphasizes eating fruits, veggies, whole grains, beans, nuts, legumes, olive oil and flavorful herbs and spices; fish and seafood at least twice a week; and poultry, eggs, cheese and yogurt in moderation,

The way of eating focuses on the quality of foods consumed rather than focusing on a single nutrient or food group

Overall, the diet is mostly plant-based and focuses on healthy fats.

...

Fish is encouraged twice weekly and other animal proteins like poultry, eggs, cheese and yogurt are encouraged in smaller portions

The main source of hydration should be water

Green tea, wild blueberries are excellent

Image Modified



Managing Body Fat ** 

...

  1. Jim Chi - a derivative of Tai Chi Quan ... supreme ultimate warrior - the Ultimate Program Tailored for You

    1. Supreme ?  No - you only compete against yourself
    2. Warrior ? No - focus on peace and preparation
    3. Ultimate ? Yes - the ultimate version of you

  2. My model for an exercise life plan ( Physical and Mental ) and focus designed by, that works for me
    1. It includes some:  aerobic, strenghtening, stretching, breathing, balance exercises all in 15 minutes a day without shock to joints ( jumping, running etc ).

  3. I encourage everyone to design their own exercise plan ( Physical and Mental ) that fits their needs

  4. I call my current program Power95
    1. I designed it be a program I could still do without damaging my body at 95
    2. I'm 75 so that's another 20 years
    3. so if I make to 95, what then?
    4. My plan is to create a new program. Power115  (smile)

  5. Physical focus tips
    1. know where you health is now before you start a program: see a doctor if you haven't recently
    2. to be your best, you need the right exercise, diet and rest that works for you
    3. if the calendar says it's an exercise day and your body says no, listen to your body
    4. exercise early to start your day right
    5. set your weekly cycle and include some off or "light" days
    6. prepare for exercise:  focus then breathing then balance then position for an exercise

  6. Mental focus tips
    1. I'm a lucky man
      1. I made it to 75 - many didn't
      2. I'm still functioning reasonably well
    2. everyday is an opportunity to focus on what you believe is most important
    3. life isn't perfect
    4. I'm definitely a work in progress
    5. but life can have perfect moments so celebrate them, share them

...

https://www.mayoclinic.org/healthy-lifestyle/fitness/expert-answers/body-weight-training/faq-20147966

include strength training exercises for all major muscle groups into a fitness routine at least two times a week.

Once you can easily do an exercise for one set of 12 to 15 repetitions, try alternative forms of the exercise to give you more resistance or challenge.

Take at least one day off between exercising each specific muscle group to give your muscles time to recover.


  • Squats
  • Squat thrusts
  • Lunges
  • Situps
  • V-ups
  • Bicycle crunches ( sit up but move one leg up and turn to touch elbow to knee )
  • Swimups ( jumping jack without the jump - add pace as needed )
  • Pushups
  • Pullups ( grab over the bar )
  • Chinups ( grab under the bar )
  • Mountain climber ( plank then alternate pull leg forward to chest ) - can add pace as needed
  • Bear Crawl ( all fours - move alternate leg and arm forward )
  • Planks  ( add alternate arm reach unders to increase difficulty )
  • Step-ups
  • Burpee - combine squat thrust with pushup ( can do 2 pushups for 1 squat thrust ) or ( do a squat legs together for better pace )

...

Take a short shower after your workout. Sweat can make your skin itchy and irritated. 

Drink water


Can you build muscle mass with bodyweight exercises?

...

Helping People Find Their Worth


Just read your post

"When I was growing up I didn’t see my type of body anywhere. Not on TV, not in the movies, not in magazines, not even with my friends. "

You are right about what we see is what we accept..

...

webmd- sex drive changes as you age

hormones play a role, it’s not always clear how much of a difference they make. But other factors -- psychological, social, and physical -- also work together to create your libido.

your 20s

Testosterone, a hormone men need for sexual arousal, is typically high in your 20s, and so is your sex drive

scientists think that female desire might go up just as fertility starts to decline toward the end of your 20s.

your 30s and 40s

testosterone starts to slowly decrease around age 35. 

for many men, the stress of work, family, and other commitments can affect how interested you are in sex

women This time of life may be when your sex drive is strongest. One study showed that women between 27 and 45 had more frequent and more intense sexual fantasies than younger or older women. They also had more sex and were more likely to have it sooner in a relationship.

pregnancy and childbirth have a big impact on your sex life

your 50s and 60s 

men - If you’re in good physical and mental health, there’s no reason you shouldn’t continue to enjoy your sex life as you get older. ED does become more common as you age. Your erections may happen less often and may be less firm. But it’s not age itself that causes the problem as much as health problems that become more common with age, like heart disease, diabetes, high cholesterol, and obesity, and the drugs that treat them.

women -  empty nest” or less worry about getting pregnant might make some women more interested in sex.  But as you head toward menopause, estrogen levels drop, which might cool your libido down a bit and lead to vaginal dryness. Hot flashes, anxiety, weight gain, and sleep problems also can make you less in the mood. Ask your doctor about medicines, hormones, lubrication, and other treatment. 

Talk about sex

Ask your partner about their needs and desires, and talk about yours, too. Don’t be afraid to try new things as your bodies evolve and your stage of life changes. This can help keep you and your partner engaged and interested in sex. Be honest about your physical and emotional satisfaction. It might even be a good idea to set aside certain times to be intimate. 


Sex tips for older women

what feels best for physical stimuatlon for older women?

It's important to talk to your partner about what feels best, as sexual arousal includes both psychological and physical aspect

There's no one-size-fits-all answer to what feels best for physical stimulation for older women, as everyone's preferences vary. However, some things that may help include:
  • Light to medium pressure
    A survey found that most women prefer light to medium pressure on the genitals, with only 1 in 10 preferring firm pressure.
  • Massage oils
    Massage oils like Zestra can create a warming sensation in the genital area and increase arousal and satisfaction.
  • Clitoral stimulation devices
    Devices like the Eros Clitoral Therapy Device can increase genital blood flow by applying a gentle vacuum to the clitoris.
  • Lubricants
    Different types of lubricants can be used, including water-based, silicone-based, natural, and oil-based.
  • Other things to try
    Other things to try include sensual massages, oral sex, and sex toys like vibrators.


safe-sex-mistakes-to-avoid

STI - If you’re sexually active, talk to your doctor about testing or visit a health clinic. They’ll take some of your blood to test or have you pee in a cup.

condoms - Only put a condom on an erect, or hard, penis. Pinch any air out of the end and roll it all the way down. When you’re finished having sex, hold the base of the condom and pull out.


Sex is good for you - webmd


its exercise
good for a womans heart
lowers stress
may cure a headache
sharpens your mind
you may live longer
makes you happy
bonds you to your partner
keeps you lean
good for mental health
helps you sleep
good for common cold
helps your future self


have-sex-now

 good for you as moderate exercise

Women who have sex a couple of times a week are less likely to get heart disease than those who have it once a month.

 “Not tonight, Dear. I have a headache.” It turns out sex can help with pain

People who have more sex are less anxious 

married women who climaxed more often had a slight tendency to live longer. 

Sex has been linked to the making of new brain cells, 

can make couples happier

sparks feelings of intimacy, affection, and closeness with your partner.

The more sex you have, the slimmer you’re likely to be. 

mental health improvement - Adults in committed relationships who have more sex are less likely to be depressed or take medication for mental health issues.

prevents colds - college students who had sex twice a week had more cold-fighting antibodies in their saliva than those who had sex less often

sleep - Orgasm triggers a surge of endorphins and oxytocin in both men and women, and that dulls pain and relaxes you

future health - If you have an active sex life in middle age, you’re more likely to keep it up as you get older, which is linked to better health and happiness.



Alzheimers Ideas


2024-06-29-The_Root_Causes_Of_Alzheimers_Disease

...

https://neurosciencenews.com/brain-age-ai-alzheimers-22192/

The brain of a forty-year-old may look as ‘young’ as the brain of a thirty-year-old, or it may look as ‘old’ as that of a sixty-year-old.”

The human brain holds many clues about a person’s long-term health — in fact, research shows that a person’s brain age is a more useful and accurate predictor of health risks and future disease than their birthdate.

...

https://medicalxpress.com/news/2023-01-previous-ideas-alzheimer-disease.html

The findings challenge the idea that simply having higher amounts of amyloid protein in general is an underlying cause of Alzheimer's, say Finch and Thorwald. Instead, the increase in soluble Aβ may be a general aging-related change in the brain not specific to Alzheimer's, while higher levels of fibrillary amyloid appear to be a better indicator of poorer brain health

Types of Dementia

Alzheimers is just one type of dementia

...

hair loss with minoxidil pills prescription

minoxidil, an old and well-known hair-loss treatment drug used in a very different way. Rather than being applied directly to the scalp, it is being prescribed in very low-dose pills.


Webmd on Hair Loss

Genes Cause 90% of Male Hair Loss

...

A group of new medications called Janus kinase (JAK) inhibitors have been approved for AD. They block a pathway that leads to the release of inflammatory chemicals in the body. Ruxolitinib (Opzelura) is available as a cream. 

Drug treatment

Dupixent cleared the skin, relieved itching, and improved quality of life in people with AD. More than half of those who took it for 16 weeks said they had 75% fewer symptoms. Those improvements last long-term.



Hair Growth

https://www.health.com/beauty/hair/best-hair-growth-serums?hid=c9e74fb017144707ceac30d1959018dd37e28399&did=880062-20221202&utm_campaign=healthy-living_newsletter&utm_source=health.com&utm_medium=email&utm_content=120222&cid=880062&mid=103521644117&lctg=175419721

...

Hair growth serums encourage a nutrient-rich environment on the scalp, activating blood vessels to carry oxygen to the follicle's root and accelerating hair growth. They can also plump up the hair cuticle, giving the appearance of thicker hair. Tiffany Young, trichologist and CEO of ThinHairThick, recommends looking for products that contain castor, rosemary, pumpkin seed oil, or menthol, natural ingredients that can alleviate dandruff, fungal infections, dryness, and some forms of alopecia.


Minoxidil, the active ingredient in our best overall pick, Rogaine for Women, has long been the gold standard in hair regrowth and is recommended by renowned dermatologists like Paul Jarrod Frank, MD. But minoxidil is not without its downside—some reported side effects include eczema and scalp irritation. Products like the Shapiro MD Hair Loss Leave-In Formula offer a minoxidil-free formula that contains DHT blockers to inhibit a hormone that can cause hair loss. If you’re looking for a plant-based formula, we recommend Vegamour Gro.


Potential Challenges




COVID issues

...

https://www.webmd.com/a-to-z-guides/do-i-have-thyroid-problem

our thyroid is a small, butterfly-shaped gland in your neck, along the front of your windpipe. It makes hormones that help control many parts of your metabolism, like how fast your heart beats and how fast you burn calories.

The most common issues with the thyroid are hypothyroidism, when the gland doesn’t make enough hormones, and hyperthyroidism, when it makes too many

hyperthyroidism

because its symptoms are a lot like those of other conditions. They can include:

...

Certain medicines can mask the signs of hyperthyroidism. If you take beta-blockers to treat high blood pressure or another condition, you might not know you have it.

Thyroid nodules

https://www.mayoclinic.org/diseases-conditions/thyroid-nodules/symptoms-causes/syc-20355262

Most thyroid nodules aren't serious and don't cause symptoms. Only a small percentage of thyroid nodules are cancerous.


Hypothyroidism

The signs can be different for everyone, and you may not notice any early on. But low levels of thyroid hormones eventually can slow down some of your body’s systems. You may:

...

https://www.webmd.com/women/guide/understanding-thyroid-problems-basics

Thyroid disorders can range from a small, harmless goiter (enlarged gland) that needs no treatment to life-threatening cancer. 



Breathing Issues and Tips

...

With the active cycle of breathing technique (ACBT), you will combine the different coughing techniques to move your breath into small and larger areas of your lungs. Gently breathe in through your nose and out through your mouth six times to relax your chest. Next, you want to move air into the small airways of your lungs. Inhale deeply and hold it for 3 seconds. Exhale softly. Last, use the huff cough technique to get the mucus out of the larger airways. Repeat the final step until you have coughed up the mucus.

Prevent infection. Protect your lungs from further harm by getting flu and pneumonia vaccines,


Natural Cough Remedies

https://www.webmd.com/cold-and-flu/ss/slideshow-natural-cough-remedies

honey - A teaspoon or two of honey may cut mucus production. Honey also kills germs.

hot tea - Hot drinks won’t ease a stuffy head, but they can soothe a cough much better than room temperature drinks.

ginger - compounds inside ginger root can relax the muscles that tighten your airways

water - Drinking lots of water not only soothes the scratch of a cough and keeps you hydrated, but it also thins the mucus in your throat.

steam - Breathing in steam may help with coughing because it calms and moisturizes your airways.

Saline irrigation, or washing out your nasal passages with a saltwater rinse, can keep inflammation down by flushing out irritants and clearing away mucus

Menthol ( Vicks ) - Menthol, a compound naturally found in peppermint, opens your airways to help you breathe more easily. 

Salt water gargle - Mix 1/4 to 1/2 of salt into 8 ounces of warm water, tip your head back, gargle, and then spit the mixture out.

cough drops - Your best bet is cough drops with airway-opening menthol.




Prednisone to reduce bronchospasms has side effects

https://www.webmd.com/asthma/guide/prednisone-asthma

Prednisone is an oral steroid medication. If you have serious worsening of asthma symptoms (an asthma attack), your doctor may prescribe a brief course of oral steroids such as prednisone. 

Sometimes systemic steroids like prednisone are taken in high doses for a few days. This is called a steroid burst. They may also be given in a low dose daily or every other day for long-term asthma control.

Side effects with short-term steroid use include:

...

Doctors may also recommend a combination of medications in order to manage a person’s blood pressure level.

Hypertension is a primary risk factor for cardiovascular disease, including stroke, heart attack, heart failure, and aneurysm. Managing blood pressure is vital for preserving health and reducing the risk of these dangerous conditions.

Exercise

Current guidelines recommend that all people, including those with hypertension, engage in at least 150 minutesTrusted Source of moderate-intensity, aerobic exercise every week, or 75 minutes per week of high-intensity exercise.

...

Can you recover from pneumonia in 3 days?
It may take time to recover from pneumonia.Some people feel better and are able to return to their normal routines in 1 to 2 weeks. For others, it can take a month or longer.

Flu Tips

Flu symptoms

You typically start to feel bad quickly instead of over time. You may have a high fever, headache and muscle aches, cough, sore throat, and tiredness. You also might have a runny or stuffy nose, chills, headache, and nausea or vomiting.

Most symptoms get better after about 5 days. But sometimes they can last for a week or more. Even if your fever and aches are gone, you can still feel drained for a few weeks.

https://www.webmd.com/cold-and-flu/flu-treatment

Ask your pharmacist which combination, if any, would be appropriate for your cough.

Which flu treatment should I take to lower my fever and body aches?

 Acetaminophen (Tylenol) or medicines like ibuprofen (Advil, Motrin) and naproxen (Aleve) are over-the-counter options for fever and pain relief. Each medication has risks. Check with your doctor or pharmacist


Is an antiviral drug a commonly used flu treatment?
Antiviral flu drugs are taken to decrease the severity and duration of flu symptoms. In some cases they may be used to prevent flu. They include baloxavir marboxil (Xofluza), oseltamivir (Tamiflu), peramivir (Rapivab), or zanamivir (Relenza).

Ideally, the first dose should be taken within 48 hours of the onset of symptoms. Most antivirals do have side effects.

Even after 48 hours, they can still help those who have a bad case of the flu, are over 65, or have a weak immune system.

Home remedies

Get lots of rest. Drink plenty of clear fluids -- water, broth, and sports drinks -- so you don't get dehydrated, too. 

Get Flu vaccine for the next season

Other Problems from the Flu

Most people recover after a few days without problems. But some get conditions like pneumonia, bronchitis, or sinus and ear infections. People who already have problems like asthma or heart failure may get sicker.

Get emergency medical help right away if you:

...

         -- Can't stop vomiting

#1  Treating Flu Symptoms

Believe it or not, those annoying symptoms you're experiencing are part of the natural healing process -- evidence that the immune system is battling illness. For instance, a fever is your body's way of trying to kill viruses by creating a hotter-than-normal environment. Also, a fever's hot environment makes germ-killing proteins in your blood circulate more quickly and effectively. Thus, if you endure a moderate fever for a day or two, you may actually get well faster. Coughing is another productive symptom; it clears your breathing passages of thick mucus that can carry germs to your lungs and the rest of your body. Even that stuffy nose is best treated mildly or not at all.

#2 Blow Your Nose Often (and the Right Way)

...

“Practicing mindfulness involves focusing on the present and noticing your thoughts and feelings without judging yourself for how you're thinking or feeling,” she says.


Exercise

Exercise increases our endorphin levels, reduces stress hormones, and improves sleep and cognition

turning your accomplishments into a ‘game’ with rewards to keep you motivated. Asking a buddy to help keep you accountable to your fitness routine


Yoga - 

https://www.webmd.com/balance/guide/the-health-benefits-of-yoga

Some types of yoga are about relaxation. In others, you move more. Most types focus on learning poses, called asanas. They also usually include attention to breathing.

At any level of yoga, you'll probably start to notice benefits soon. In one study, people improved their flexibility by up to 35% after only 8 weeks of yoga.

Some styles of yoga, such as ashtanga and power yoga, are very physical. Practicing one of these styles will help you improve muscle tone.

...

Yoga nidra or yogic sleep in modern usage is a state of consciousness between waking and sleeping, typically induced by a guided meditation



health eating - it's what you eat, not how much

...

Scientists Claim Overeating Is Not the Primary Cause of Obesity Point to More Effective Weight Loss .pdf


90% of the serotonin in our bodies, which is necessary to maintain a stable mood, is made in the gut. We need healthy fuel and good bacteria for our brains to run efficiently and stay happy.

avoiding refined sugar when possible, which can make people more susceptible to depression and anxiety. Other healthy choices involve increasing vegetable intake, eating unprocessed grains, swapping out meat for fish, and reducing dairy, as Dr. Kennedy shares.


weight loss


Be in Nature


120 minutes per week spent in nature can lead to better health and overall wellbeing, and this includes your mental health. And it can be as easy as taking a walk in your neighborhood.

“Being in nature reduces our stress levels and can improve our cognition,” Dr. Kennedy says. “Getting outside and exercising can be an impactful way to reap mental health benefits. Doing a walking meditation outdoors and paying attention to all five senses and what they are perceiving can also produce a calming, centered effect.


Connections to Others


“Maintaining social connections is important. As human beings, we are relational people. We need each other, whether we think we do or not. Maintaining social connections is an important way to feel less isolated, to engage in hobbies, relax, and have fun, but also a way to feel support when experiencing difficult times.”

Reaching out to a friend or connecting with a family member each day can increase feelings of well-being. Even chatting with a stranger and making small talk can reinforce feelings about the goodness of humanity and boost our feelings of connectedness to others


eyes 


new lab-grown retinal cells may restore sight

...

“Rogaine is probably one of the few things that’s been actually FDA-approved and worked out to help grow hair,” says Dr. Michele Green, a board-certified dermatologist in New York City. The active ingredient in Rogaine products, including this foam, is minoxidil, which stimulates hair growth. Both the men and women’s foams contain 5% of minoxidil, but Rogaine recommends men apply a half capful twice a day directly to the scalp in the hair loss area. For women, the brand recommends applying half a capful just once a day. You can expect to see results in 120 days, but keep in mind that continued use is necessary to keep any results, according to the brand.





Cancer Diagnostics



Cancer Risks


https://www.yahoo.com/lifestyle/cancer-rates-millennials-gen-x-223840571.html


New England MRI / PET scans

...

cancer-lunasin-ncbi.nlm.nih.gov-Lunasin and Its Epigenetic Impact in Cancer Chemoprevention.pdf. file


cancer prevention. A healthy body maintains a balance between cell division and cell loss. Any disturbance can result in uncontrolled and excessive proliferation and the development of neoplastic disease. The major cancer risk factors include tobacco use, occupational carcinogens, improper diet, pathogens or environmental carcinogens 

it is pivotal to search for bioactive dietary compounds that can avert tumor development. A diet rich in vegetables, including legumes, provides chemopreventive substances, which have the potential to prevent many diseases, including cancer. Lunasin is a soy-derived peptide whose anti-cancer activity has been studied for over 20 years. The results of the previous research have shown that lunasin inhibits histone acetylation, regulates the cell cycle, suppresses proliferation and induces apoptosis of cancer cells. Thus, lunasin seems to be a promising bioactive anti-cancer agent and a potent epigenetic modulator. The present review discusses studies of the underlying molecular mechanisms and new perspectives on lunasin application in epigenetic prevention and anti-cancer therapy.

Previous studies have shown that lunasin possesses epigenetic anti-cancer activity, as its anti-mitotic effects have been attributed to its binding to regions of hypoacetylated chromatin [8]. In healthy cells, the level of histone acetylation and deacetylation is balanced. Histone acetylation results in the relaxation of the chromatin structure, which increases gene expression [3,8]. Lunasin has been shown to compete with histone acetyltransferases (HATs) and prevent the attachment of acetyl groups to deacetylated histones of the selected genes, including those with oncogenic potential [3]; thus, lunasin inhibits their overexpression which might reduce the risk of tumor development and progression [9]. Surprisingly, a limited number of HATs inhibitors have been identified and described, knowing that aberrant HAT activities in cell signaling can trigger cancer development. Therefore, lunasin has a chance to become a new agent with epigenetic chemotherapeutic potential.



MS - Multiple Sclerosis



MS Summary

...

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that occurs when the body's immune system attacks the brain and spinal cord, damaging the insulating covers of nerve cells: 

InMS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body. Eventually, the disease can cause permanent damage or deterioration of the nerve fibers

there are treatments to help speed the recovery from attacks, modify the course of the disease and manage symptoms.

MS Treatments


Expand
titleMS Treatments

Treatments for MS attacks

  • Corticosteroids, such as oral prednisone and intravenous methylprednisolone, are prescribed to reduce nerve inflammation. Side effects may include insomnia, increased blood pressure, increased blood glucose levels, mood swings and fluid retention.
  • Plasma exchange (plasmapheresis). The liquid portion of part of your blood (plasma) is removed and separated from your blood cells. The blood cells are then mixed with a protein solution (albumin) and put back into your body. Plasma exchange may be used if your symptoms are new, severe and haven't responded to steroids.

Treatments to modify progression

There are several disease modifying therapies (DMTs) for relapsing-remitting MS. Some of these DMTs can be of benefit for secondary progressive MS, and one is available for primary progressive MS.

Much of the immune response associated with MS occurs in the early stages of the disease. Aggressive treatment with these medications as early as possible can lower the relapse rate, slow the formation of new lesions, and potentially reduce risk of brain atrophy and disability accumulation.

Many of the disease-modifying therapies used to treat MS carry significant health risks. Selecting the right therapy for you will depend on careful consideration of many factors, including duration and severity of disease, effectiveness of previous MS treatments, other health issues, cost, and child-bearing status.

Treatment options for relapsing-remitting MS include injectable, oral and infusions medications.

Injectable treatments include:

  • Interferon beta medications. These drugs used to be the most prescribed medications to treat MS. They work by interfering with diseases that attack the body and may decrease inflammation and increase nerve growth. They are injected under the skin or into muscle and can reduce the frequency and severity of relapses.

    Side effects of interferons may include flu-like symptoms and injection-site reactions. You'll need blood tests to monitor your liver enzymes because liver damage is a possible side effect of interferon use. People taking interferons may develop neutralizing antibodies that can reduce drug effectiveness.

  • Glatiramer acetate (Copaxone, Glatopa). This medication may help block your immune system's attack on myelin and must be injected beneath the skin. Side effects may include skin irritation at the injection site.
  • Monoclonal antibodies. Ofatumumab (Kesimpta, Arzerra) targets cells that damage the nervous system. These cells are called B cells. Ofatumumab is given by an injection under the skin and can decrease multiple sclerosis brain lesions and worsening symptoms. Possible side effects are infections, local reactions to the injection and headaches.

Oral treatments include:

  • Teriflunomide (Aubagio). This once-daily oral medication can reduce relapse rate. Teriflunomide can cause liver damage, hair loss and other side effects. This drug is associated with birth defects when taken by both men and women. Therefore, use contraception when taking this medication and for up to two years afterward. Couples who wish to become pregnant should talk to their doctor about ways to speed elimination of the drug from the body. This drug requires blood test monitoring on a regular basis.
  • Dimethyl fumarate (Tecfidera). This twice-daily oral medication can reduce relapses. Side effects may include flushing, diarrhea, nausea and lowered white blood cell count. This drug requires blood test monitoring on a regular basis.
  • Diroximel fumarate (Vumerity). This twice-daily capsule is similar to dimethyl fumarate but typically causes fewer side effects. It's approved for the treatment of relapsing forms of MS.
  • Monomethyl fumarate (Bafiertam) was approved by the FDA as a delayed release medicine that has a slow and steady action. Because of its time release, it is hoped that side effects will be decreased. Possible side effects are flushing, liver injury, abdominal pain and infections.
  • Fingolimod (Gilenya). This once-daily oral medication reduces relapse rate.

    You'll need to have your heart rate and blood pressure monitored for six hours after the first dose because your heart rate may be slowed. Other side effects include rare serious infections, headaches, high blood pressure and blurred vision.

  • Siponimod (Mayzent). Research shows that this once-daily oral medication can reduce relapse rates and help slow progression of MS. It's also approved for secondary-progressive MS. Possible side effects include viral infections, liver problems and low white blood cell count. Other possible side effects include changes in heart rate, headaches and vision problems. Siponimod is harmful to a developing fetus, so women who may become pregnant should use contraception when taking this medication and for 10 days after stopping the medication. Some might need to have the heart rate and blood pressure monitored for six hours after the first dose. This drug requires blood test monitoring on a regular basis.
  • Ozanimod (Zeposia). This oral medication decreases the relapse rate of multiple sclerosis and is given once a day. Possible side effects are an elevated blood pressure, infections and liver inflammation.
  • Ponesimod (Ponvory). This oral medication is taken once a day with a gradually increasing dosing schedule. This medicine has a low relapse rate and has demonstrated fewer brain lesions than some other medications used to treat multiple sclerosis. The possible side effects are respiratory tract infections, high blood pressure, liver irritation and electrical problems in the heart that affect heart rate and rhythm.
  • Cladribine (Mavenclad). This medication is generally prescribed as a second line treatment for those with relapsing-remitting MS. It was also approved for secondary-progressive MS. It is given in two treatment courses, spread over a two-week period, over the course of two years. Side effects include upper respiratory infections, headaches, tumors, serious infections and reduced levels of white blood cells. People who have active chronic infections or cancer should not take this drug, nor should women who are pregnant or breastfeeding. Men and women should use contraception when taking this medication and for the following six months. You may need monitoring with blood tests while taking cladribine.

Infusion treatments include:

  • Natalizumab (Tysabri). This is a monoclonal antibody that has been shown to decrease relapse rates and slow down the risk of disability.

    This medication is designed to block the movement of potentially damaging immune cells from your bloodstream to your brain and spinal cord. It may be considered a first line treatment for some people with severe MS or as a second line treatment in others.

    This medication increases the risk of a potentially serious viral infection of the brain called progressive multifocal leukoencephalopathy (PML) in people who are positive for antibodies to the causative agent of PML JC virus. People who don't have the antibodies have extremely low risk of PML.

  • Ocrelizumab (Ocrevus). This treatment reduces the relapse rate and the risk of disabling progression in relapsing-remitting multiple sclerosis. It also slows the progression of the primary-progressive form of multiple sclerosis.

    This humanized monoclonal antibody medication is the only DMT approved by the FDA to treat both the relapse-remitting and primary-progressive forms of MS. Clinical trials showed that it reduced relapse rate in relapsing disease and slowed worsening of disability in both forms of the disease.

    Ocrelizumab is given via an intravenous infusion by a medical professional. Infusion-related side effects may include irritation at the injection site, low blood pressure, a fever and nausea, among others. Some people may not be able to take ocrelizumab, including those with a hepatitis B infection. Ocrelizumab may also increase the risk of infections and some types of cancer, particularly breast cancer.

  • Alemtuzumab (Campath, Lemtrada). This treatment is a monoclonal antibody that decreases annual relapse rates and demonstrates MRI benefits.

    This drug helps reduce relapses of MS by targeting a protein on the surface of immune cells and depleting white blood cells. This effect can limit potential nerve damage caused by the white blood cells. But it also increases the risk of infections and autoimmune disorders, including a high risk of thyroid autoimmune diseases and rare immune mediated kidney disease.

    Treatment with alemtuzumab involves five consecutive days of drug infusions followed by another three days of infusions a year later. Infusion reactions are common with alemtuzumab.

    The drug is only available from registered providers, and people treated with the drug must be registered in a special drug safety monitoring program. Alemtuzumab is usually recommended for those with aggressive MS or as second line treatment for patients who failed another MS medication.

Recent developments or emerging therapies

Bruton's tyrosine kinase (BTK) inhibitor is an emerging therapy being studied in relapsing-remitting multiple sclerosis and secondary-progressive multiple sclerosis. It works by mostly modulating B cells, which are immune cells in the central nervous system.

Stem cell transplantation destroys the immune system of someone with multiple sclerosis and then replaces it with transplanted healthy stem cells. Researchers are still investigating whether this therapy can decrease inflammation in people with multiple sclerosis and help to "reset" the immune system. Possible side effects are fever and infections.

Researchers are learning more about how existing disease modifying therapies work to lessen relapses and reduce multiple sclerosis-related lesions in the brain. Further studies will determine whether treatment can delay disability caused by the disease.

For primary-progressive MS, ocrelizumab (Ocrevus) is the only FDA-approved disease-modifying therapy (DMT). Those who receive this treatment are slightly less likely to progress than those who are untreated.

For secondary progressive MS, some might consider the use of FDA-approved disease modifying therapies such as ozanimod, siponimod and cladribine, which can potentially slow down disabilities.

Multiple sclerosis - World Health Organization (WHO)
Aug 7, 2023 —Overview. Multiple sclerosis (MS) is a condition that happens when the immune system attacks the brain and spinal cord. Symptoms of MS vary from person to person and depend on the location and severity of nerve fibre damage. These often include vision problems, tiredness, trouble walking and keeping balance, and numbness or weakness in the arms and legs. Symptoms can come and go or last for a long time. The causes of MS are not known but a family history of the disease may increase the risk. While there is no cure for MS, treatment can reduce symptoms, prevent further relapses and improve quality of life.
Multiple sclerosis (MS) - common symptoms - Better Health Channel
Jun 16, 2021 — Summary. Multiple sclerosis (MS) is a disease of the central nervous system that can affect the brain, spinal cord and optic nerves. Common symptoms include fatigue, bladder and bowel problems, sexual problems, pain, cognitive and mood changes such as depression, muscular changes and visual changes.
Symptoms of MS can vary from person to person, depending on the severity and location of nerve damage. Some people may only experience mild symptoms, while others may have severe, chronic symptoms that never go away. Symptoms can include:
  • Vision problems, such as blurred or double vision, red-green color distortion, or vision loss
  • Fatigue
  • Trouble walking and keeping balance
  • Numbness, prickling, or pins and needles in the arms, legs, or face
  • Muscle weakness in the arms and legs
  • Pain
  • Cognitive and mood changes, such as depression
  • Bladder and bowel problems
  • Sexual problems 
Although there is no cure for MS, treatments can help reduce symptoms, prevent relapses, and improve quality of life. These treatments include: medications that suppress the immune system, immunomodulatory therapy, physical and occupational therapy, and disease-modifying agents. 
Risk factors for MS include:
  • Family history
  • Certain infections, such as the Epstein-Barr virus that causes mono
  • Autoimmune thyroid disease, pernicious anemia, psoriasis, type 1 diabetes, or inflammatory bowel disease 
MS is more prevalent in people of northern and southern latitudes, including Canada, the northern US, New Zealand, southeastern Australia, and Europe. White people, especially those of northern European descent, are at the highest risk, while people of Asian, African, and Native American ancestry have the lowest risk. 
This is for informational purposes only. For medical advice or diagnosis, consult a professional. Generative AI is experimental.

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